Buy Lexapro

Generalized anxiety disorder: study shows Lexapro better tolerated than Paxil

LOSS OF PATENT protection on Pfizer’s Zoloft last year caused analysts to raise warning flags about the whole class. But the surprisingly strong performance of Forest Labs’ Lexapro brought reassuring news. Forest said last month that Lexapro earned $545.9 million for the three months ended Dec. 31, compared to $480.7 million in the period a year prior. That’s a 13.6% gain for the selective serotonin reuptake inhibitor (SSRI,purchase cheap generic lexapro,order right now), which is indicated for the initial and maintenance treatment of major depressive disorder and generalized anxiety disorder.

MIAMI — Escitalopram is as effective as paroxetine, but is better tolerated, for long-term treatment of generalized anxiety disorder, Dr. Robert J. Bielski said at the annual conference of the Anxiety Disorders Association of America.Selective serotonin reuptake inhibitors (SSRIs,purchase lexapro) are increasingly being prescribed for generalized anxiety disorder, according to Dr. Bielski, a researcher at Summit Research Network in Okemos, Mich., which conducts clinical trials for pharmaceutical companies, including Forest Labs Inc., the maker of escitalopram (Lexapro).

In a rare direct comparison, he and his colleagues assessed the efficacy and tolerability of escitalopram and paroxetine (Paxil), two agents approved by the Food and Drug Administration for treating generalized anxiety disorder. (Extended-release venlafaxine is also FDA approved for this condition,cheap generic lexapro.)

All participants met the DSM-IV definition for generalized anxiety disorder: a baseline score on the Hamilton Anxiety Scale of 18 or more. Mean age was 37 years. There were 60 patients randomized to escitalopram and 61 to paroxetine. The study began with a week of single-blind placebo treatment, followed by 24 weeks of double-blind, flexible-dose treatment with either 10-20 mg/day of escitalopram or 20-50 mg/day of paroxetine. After an additional 2 weeks to titrate participants down, their Hamilton anxiety scores were compared for mean change from baseline.

Efficacy was similar; both agents improved anxiety symptoms. The mean baseline Hamilton anxiety score was 23.7 in the escitalopram group and 23.4 in the paroxetine group. At the end of the study, the mean reduction in scores was 15.3 in the escitalopram group and 13.3 in the paroxetine group.

“The SSRIs are a family of antidepressants that are really revolutionary. They are so much better tolerated than their predecessors,” Dr. Bielski said at the meeting.

A representative of GlaxoSmithKline, the maker of paroxetine, declined to comment on the findings.There were differences in adverse effects between the two treatment groups. The researchers noted the most frequent adverse events in 10% or more of patients. In the escitalopram group, diarrhea (21%), upper respiratory tract infection (15%), and fatigue (12%) were most common. In the paroxetine group, ejaculation disorder (30%), anorgasmia (26%), and insomnia (26%) were most common.There was a statistically significant difference in the numbers of patients who withdrew from the study because of adverse events, Dr. Bielski said. A total of 6.6% withdrew from the escitalopram group, compared with 22.6% of the paroxetine group.